Better performing IV connector with Covestro polycarbonate

Better performing IV connectors with Makrolon® polycarbonate

The right choice for oncology drug delivery

Approximately 40 percent of people will be diagnosed with cancer in their lifetime. During treatment, everything must work as designed, down to the plastic used in IV connectors.

An IV connector formed from Makrolon® Rx3440 polycarbonate from Covestro offers superior durability and oncology drug resistance.


Some cancer drugs contain aggressive solvents - these solvents dissolve, or attack, the plastic materials used in luers and other IV connectors that help deliver oncology drugs. To prevent part damage, a medical OEM sought a plastic material with increased chemical resistance for its luer connector.


The selected material needed to have increased oncology drug resistance to address attacks from solvents including benzyl alcohol and dimethyl acetamide that can result in cracking or damage. The OEM also needed a material that could be utilized with minimal validation and requalification.


Makrolon® Rx3440 polycarbonate was selected for the luer connector due to its oncology drug resistance. Compared to transparent competitive materials, this material also demonstrated the best retention of stress and best overall combination of physical properties. A Covestro-designed novel testing apparatus was used to test the luer connector against oncology simulants and a common disinfectant, enabling immersion testing under real-life loading to prove its chemical resistance and toughness.

Case Profile




Covestro LLC


Fluid connectors, luers and other IV access components

Makrolon® polycarbonate - the state of the art material for a broad range of design applications that possesses phenomenal properties

  • Makrolon® Rx3440 polycarbonate offers superior oncology drug resistance to provide more reliable IV connections, demonstrating ongoing innovation in healthcare.
  • Due to its impact resistance and structural integrity, the material is appropriate for thin-wall medical applications.
  • This grade is resistant to heat, meaning it retains its original shape when exposed to a variety of conditions during shipping or storage.
  • Makrolon® Rx3440 polycarbonate is biocompatible according to ISO 10993-1 and USP Class IV standards, meaning it is tested for human contact.
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